Does Diastolic Dysfunction Precede Systolic Dysfunction Following Contemporary Breast Cancer Therapy?

Does diastolic dysfunction precede systolic dysfunction in trastuzumab-induced cardiotoxicity? Assessment with multigated radionuclide angiography (MUGA)

BACKGROUND Trastuzumab is successfully used for the treatment of HER2-positive breast cancer. Because of its association with cardiotoxicity, LVEF is monitored by MUGA, though this is a relatively late measure of cardiac function. Diastolic dysfunction (DD) is believed to be an early predictor of cardiac impairment. We evaluate the merit of MUGA-derived diastolic function parameters in the earl...

Sexual Dysfunction in Breast Cancer Survivors

Background: Approximately 12.3 percent of women will be diagnosed with breast cancer at some point during their lifetime. Breast cancer is accompanied by alternation in body image and worries about sexual attractiveness. Thus, sexual life of breast cancer survivor’s needs special attention. This study aimed to evaluate the effects of breast cancer on women’s sexual function.  ...

Diastolic Mechanisms for Systolic Dysfunction During Exercise

many patients with essential hypertension. To assess the determinants of the abnormal ejection fraction response to exercise, we performed radionuclide angiography at rest and during exercise in 41 hypertensive patients without coronary artery disease. In 22 patients (group 1), the ejection fraction increased more than 5% during exercise; in the other 19 patients (group 2), the ejection fractio...

Diastolic dysfunction does ethnicity matter?

Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet.

BACKGROUND Although hypercholesterolemia is a well-established risk factor for coronary artery disease, little is known regarding its direct effects on cardiac function. METHODS AND RESULTS We examined the effects of cholesterol feeding (0.5%) on cardiac function in rabbits. After 10 weeks, both systolic shortening and diastolic relaxation rates were impaired without any change in aortic pres...